ABSTRACT
Introduction: Infection with SARS-CoV-2 induces a prothrombotic state in patients, by the combination of hyperinflammatory response and hypoxia. In Cuba, the drug called Jusvinza, based on an immunomodulatory peptide, is used for the treatment of patients with COVID-19, who present signs and symptoms of hyperinflammation. Objectives: To describe the clinical course and behavior of various biomarkers associated with the inflammation and coagulation, in a group of critically ill patients with COVID-19 treated with Jusvinza, compared to a group of patients who did not receive treatment with this peptide. Methods: 40 critically ill patients with COVID-19 were included. The patients were divided into 2 groups: 20 patients were treated with Jusvinza and 20 were not treated with this peptide (control group). Demographic characteristics, comorbidities, vital signs, respiratory parameters and inflammation and coagulation biomarkers were obtained from the medical records of each patient. Results: Treatment with Jusvinza induced a clinical improvement in the patients, associated with the decrease of several inflammation and coagulation biomarkers. Patients treated with Jusvinza had a significantly higher survival than patients not treated with this peptide. Conclusions: Jusvinza is able to control hyperinflammation and hypercoagulation in critical ill patients with COVID-19. © 2021, Editorial Ciencias Medicas. All rights reserved.
ABSTRACT
An attempt has been made to develop an algorithm for banks to check the credibility of borrowers to avoid nonperformance assets. People move towards different banks for loan purpose to fulfil their financial needs. Approaching bank for loan is increasing day by day mainly for child marriage, education, agriculture, business, home loan etc. Some people take the loan and they won't pay back in time or some will move out of the country without any intimation, so that bank will go in loss. Even now in covid-19 pandemic many industries were closed but they need to give salary to the employees, need to pay rent and electricity bills too for that they will approach bank for loan. For all these cases bank first need to analyse their Credit Information Bureau India Limited score and check whether they had done loan repayments in appropriate time or not. In the present work the effectiveness of K nearest neighbor algorithm were analysed. This research were carried out using python. The accuracy of this classifier is analysed using following metrics such as Jaccard index, F1-score and LogLoss. This helps to find the potential of the customer which is much higher than the data mining classification algorithm and thus it helps in sanctioning loans. © 2021 The authors and IOS Press.
ABSTRACT
Introduction: CIGB-258 is an immunomodulatory peptide with anti-inflammatory properties. Objectives: To establish the therapeutic schedule with CIGB-258 peptide for COVID-19 critically ill patients. In addition, to define the criteria for use and schedule of this peptide for COVID-19 seriously ill patients. Methods: 9 critically ill patients and 3 seriously ill patients were included in this study. Clinical, radiological and laboratory evaluations were recorded according to the established protocol. Serum samples were obtained before and after treatment with CIGB-258, for the determination of the inflammation biomarkers. Results: The therapeutic protocol was established with the CIGB-258 peptide, which consists of intravenous administration of 1 mg of peptide every 12 hours for critically ill patients. The dose should be increased to 2 mg every 12 hours, for patients who do not show clinical and radiological improvement in 24 hours. After extubation, patients should receive 1 mg of CIGB-258 daily, for another three days. Seriously ill patients should receive 1 mg of CIGB-258 every 12 hours, until their clinical condition resolves. Conclusions: CIGB-258 showed an excellent safety profile. The established therapeutic protocol contributed to all critically ill patients recovering from respiratory distress and being extubated. Seriously ill patients improved considerably. The levels of the biomarkers associated with hyperinflammation and cytokines decreased significantly during treatment. © 2020, Editorial Ciencias Medicas. All rights reserved.